Coupling of the TCR to integrin activation by Slap-130/Fyb.
Science
; 293(5538): 2263-5, 2001 Sep 21.
Article
em En
| MEDLINE
| ID: mdl-11567141
SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals.
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Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Proteínas de Transporte
/
Antígeno-1 Associado à Função Linfocitária
/
Proteínas Adaptadoras de Transdução de Sinal
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article