Your browser doesn't support javascript.
loading
Baclofen attenuates harmaline induced tremors in rats.
Tariq, M; Arshaduddin, M; Biary, N; Al Moutaery, K; Al Deeb, S.
Afiliação
  • Tariq M; Research Center, Armed Forces Hospital, P.O. Box 7897 (W-912), Riyadh 11159, Saudi Arabia.
Neurosci Lett ; 312(2): 79-82, 2001 Oct 19.
Article em En | MEDLINE | ID: mdl-11595339
Recent experimental and clinical studies clearly suggest the role of gamma-aminobutyric acid (GABA) in the pathogenesis of tremors. The present study was undertaken to investigate the effect of baclofen, a GABA B receptor agonist on harmaline induced tremors. Four groups of female Wistar rats weighing 100+/-15 g were injected with harmaline (10 mg/kg, intraperitoneally) for inducing experimental tremors. The animals in groups 2, 3 and 4 were given baclofen by gavage at doses of 2.5, 5 and 10 mg/kg, respectively, half an hour before harmaline administration, whereas, the rats in group 1 served as control and received water. The latency of onset, intensity and duration of tremor and electromyographic (EMG) responses were recorded. Treatment with baclofen resulted in a dose dependent decrease in the intensity of tremor. Our EMG study also revealed a significant decrease in the amplitude of tremors in baclofen treated rats. A highly significant increase in latency of onset of tremor was observed in the rats treated with high dose (10 mg/kg) of baclofen only. This study clearly suggests beneficial effects of baclofen in harmaline induced tremors.
Assuntos
Buscar no Google
Base de dados: MEDLINE Assunto principal: Baclofeno / Tremor / Receptores de GABA-B / Agonistas GABAérgicos / Tremor Essencial / Ácido gama-Aminobutírico / Harmalina Limite: Animals Idioma: En Ano de publicação: 2001 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Baclofeno / Tremor / Receptores de GABA-B / Agonistas GABAérgicos / Tremor Essencial / Ácido gama-Aminobutírico / Harmalina Limite: Animals Idioma: En Ano de publicação: 2001 Tipo de documento: Article