Epibatidine, a nicotinic acetylcholine receptor agonist, inhibits the capsaicin response in dorsal root ganglion neurons.
Brain Res
; 919(1): 166-8, 2001 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-11689175
ABSTRACT
In patch-clamp recordings from small-medium diameter dorsal root ganglion neurons in culture, (+/-)-epibatidine (1 microM) was able to inhibit the capsaicin response (IC(50)=0.32 microM) in neurons where there was no detectable direct nicotinic response. Thus, (+/-)-epibatidine may inhibit the vanilloid receptor in a manner that is not dependent upon nicotinic current activation, representing another mechanism by which such ligands could modulate vanilloid receptor signaling.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Piridinas
/
Capsaicina
/
Receptores Nicotínicos
/
Agonistas Nicotínicos
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Gânglios Espinais
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article