Alkylthiocolchicines and N-deacetyl-alkylthiocolchicines and their antileukemic activity.
J Pharm Sci
; 64(4): 646-8, 1975 Apr.
Article
em En
| MEDLINE
| ID: mdl-1170315
ABSTRACT
A series of alkylthiocolchcines (methyl, ethyl, n-butyl, n-hexy, n-octyl, and pinanyl) was prepared from colchicine by treatment with the appropriate alkyl mercaptan and p-toluenesulfonic acid. Some of these compounds (methyl-, ethyl-, and n-butylthiocolchicines) were deacetylated in good yields with 2 N hydrochloric acid in methanol. These compounds were tested for their antileukemic activity in an in vitro assay against L-1210 (mouse leukemia). Preliminary results showed that methylthiocolchicine is more active and the other alkylthiocolchicines are much less active than colchicine. N-Deacetyl-methylthiocolchicine is as active as colchicine.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia L1210
Limite:
Animals
Idioma:
En
Ano de publicação:
1975
Tipo de documento:
Article