A comparison of artesunate alone with combined artesunate and quinine in the parenteral treatment of acute falciparum malaria.
Trans R Soc Trop Med Hyg
; 95(5): 519-23, 2001.
Article
em En
| MEDLINE
| ID: mdl-11706665
ABSTRACT
In some areas clinicians have combined parenteral artesunate and quinine in the belief that the 2 drugs would be additive or synergistic in severe malaria. A randomized comparison of the effectiveness of intravenous (i.v.) artesunate versus i.v. artesunate and i.v. quinine together on parasite clearance was conducted in 1998/99 amongst 69 patients with uncomplicated and severe Plasmodium falciparum malaria in western Thailand. The parasite clearance time did not differ significantly between the 2 treatment groups (P = 0.12), but adverse events were significantly more frequent in the artesunate plus quinine group (P = 0.05). Quinine did not have a significant antipyretic effect and artesunate did not affect the electrocardiographic QTc interval. There is no benefit evident from combining parenteral administration of these 2 antimalarial drugs in the acute phase of treatment.
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Base de dados:
MEDLINE
Assunto principal:
Quinina
/
Sesquiterpenos
/
Malária Falciparum
/
Artemisininas
/
Antimaláricos
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article