Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.
J Neurosci
; 21(23): 9499-505, 2001 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-11717384
ABSTRACT
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dronabinol
/
Comportamento Animal
/
Dinorfinas
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Transtornos Relacionados ao Uso de Substâncias
Limite:
Animals
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article