Stereoselective synthesis of 2-amino-3-fluoro bicyclo[3.1.0]hexane-2,6-dicarboxylic acid.
Bioorg Med Chem
; 10(2): 433-6, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11741791
ABSTRACT
(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740) is a conformationally restricted glutamate analogue that is a potent, selective and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties. Herein, we describe a stereoselective and highly efficient synthesis of its 3-beta fluoro derivative using the Corey-Link methodology to create the amino acid stereogenic center.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Bicíclicos com Pontes
/
Bioquímica
/
Cicloexanos
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article