MELTING, computing the melting temperature of nucleic acid duplex.
Bioinformatics
; 17(12): 1226-7, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11751232
ABSTRACT
UNLABELLED MELTING computes the enthalpy and entropy of an oligonucleotide duplex helix-coil transition, and then its melting temperature. The program uses the method of nearest-neighbours. The set of thermodynamic parameters can be easily customized. The program provides several correction methods for the concentration of salt. MELTING is a free program, available at no cost and open-source. Perl scripts are provided to show how MELTING can be used to construct more ambitious programs. AVAILABILITY:
MELTING is available for several platforms (http//www.pasteur.fr/recherche/unites/neubiomol/meltinghome.html) and is accessible via a www server (http//bioweb.pasteur.fr/seqanal/interfaces/melting.html). CONTACT nl223@cus.cam.ac.uk
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Base de dados:
MEDLINE
Assunto principal:
Software
/
Ácidos Nucleicos
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article