Increased density of galanin binding sites in the dorsal raphe in a genetic rat model of depression.
Neurosci Lett
; 317(2): 101-5, 2002 Jan 11.
Article
em En
| MEDLINE
| ID: mdl-11755250
ABSTRACT
The Flinders Sensitive Line rats showed an increased immobility response by 104% (P<0.01) in the forced swim test with respect to the Flinders Resistant Line rats (control). The Flinders Sensitive Line rats also had an increase of [(125)I]galanin (porcine) binding in the dorsal raphe (55+/-3.3 fmol/mg protein) with respect to the Flinders Resistant Line rats (38+/-3.6 fmol/mg protein) (42%, P<0.05) without changes in galanin receptor affinity and with a significant reduction (32.3%, P<0.05) of galanin-like immunoreactivity in the dorsal raphe. The results indicate that enhancement of galanin receptor function in the dorsal raphe rich in 5-HT neurons could be a mechanism involved in the production of depressive-like activity in this animal model of depression.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Núcleos da Rafe
/
Receptores de Neuropeptídeos
/
Galanina
/
Depressão
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article