Oxidative behaviour of apomorphine and its metabolites.

Garrido, J M P J; Delerue-Matos, C; Borges, M F M; Macedo, T R A; Oliveira-Brett, A M

Garrido, J M P J; Delerue-Matos, C; Borges, M F M; Macedo, T R A; Oliveira-Brett, A M.

Afiliação

Garrido JM; CEQUP/Dep. Eng. Química, Instituto Superior de Engenharia do Porto, Rua S. Tomé, 4200-485 Porto, Portugal.

Bioelectrochemistry ; 55(1-2): 113-4, 2002 Jan.

Article em En | MEDLINE | ID: mdl-11786353

ABSTRACT

ABSTRACT

The metabolism of apomorphine is quite complex due to interactions with proteins and other tissue components that affect its pharmacokinetic profile. The electrochemical oxidation mechanism of apomorphine and of some synthesised apomorphine derivatives was studied. It was found to be related to the reaction of o-diphenol and tertiary amine groups and strongly dependent on pH.

Assuntos

Apomorfina/metabolismo; Apomorfina/química; Concentração de Íons de Hidrogênio; Oxirredução

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