The role of p53 and pRB in apoptosis and cancer.
Curr Opin Genet Dev
; 12(1): 60-6, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11790556
ABSTRACT
Loss of function of both the p53 pathway and the retinoblastoma protein (pRB) pathway plays a significant role in the development of most human cancers. Loss of pRB results in deregulated cell proliferation and apoptosis, whereas loss of p53 desensitizes cells to checkpoint signals, including apoptosis. In the past two years, mouse genetics and gene expression profiling have led to major advances in our understanding of how the pRB and p53 pathways regulate apoptosis and thus the development of tumours.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Proteína Supressora de Tumor p53
/
Proteína do Retinoblastoma
/
Apoptose
/
Proteínas de Ciclo Celular
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article