Parametric linkage analysis and disequilibrium methods to identify loci for complex disease.
Genet Epidemiol
; 21 Suppl 1: S528-33, 2001.
Article
em En
| MEDLINE
| ID: mdl-11793731
ABSTRACT
A two-step process was used to find loci contributing to the qualitative disease phenotype in the Genetic Analysis Workshop (GAW) 12 simulated data. The first step used parametric linkage analysis with a limited number of dominant and recessive models to detect linkage to chromosomal regions. Subsequently, a subset of the simulated biallelic sequence polymorphisms was used for transmission/disequilibrium tests and to build haplotypes to fine map the disease-predisposing polymorphism(s). A haplotype, strongly associated with the disease phenotype whose proximal end was within 39 base pairs of the functional allele for simulated major gene 6, was identified in the isolated population.
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Base de dados:
MEDLINE
Assunto principal:
Fenótipo
/
Desequilíbrio de Ligação
/
Mapeamento Cromossômico
/
Predisposição Genética para Doença
Tipo de estudo:
Prognostic_studies
/
Qualitative_research
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article