Militarinone A, a neurotrophic pyridone alkaloid from Paecilomyces militaris.
Org Lett
; 4(2): 197-9, 2002 Jan 24.
Article
em En
| MEDLINE
| ID: mdl-11796049
ABSTRACT
[structure see text] A new pyridone alkaloid, militarinone A (1), was isolated by bioassay-guided fractionation from the mycelium of the entomogenous fungus Paecilomyces militaris. Its structure was established by extensive spectroscopic analysis. The compound features an unprecedented side chain and a 1,4-substituted cyclohexyl moiety not previously encountered in microbial metabolites. Militarinone A had a pronounced neurotrophic effect in PC-12 cells at 10 microM concentrations.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Paecilomyces
/
Alcaloides
/
Fatores de Crescimento Neural
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article