HLA-B*35-restricted CD8(+)-T-cell epitope in Mycobacterium tuberculosis Rv2903c.
Infect Immun
; 70(2): 981-4, 2002 Feb.
Article
em En
| MEDLINE
| ID: mdl-11796635
ABSTRACT
Few human CD8(+) T-cell epitopes in mycobacterial antigens have been described to date. Here we have identified a novel HLA-B*35-restricted CD8(+) T-cell epitope in Mycobacterium tuberculosis Rv2903c based on a reverse immunogenetics approach. Peptide-specific CD8 T cells were able to kill M. tuberculosis-infected macrophages and produce gamma interferon and tumor necrosis factor alpha.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antígeno HLA-B35
/
Linfócitos T CD8-Positivos
/
Epitopos de Linfócito T
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Mycobacterium tuberculosis
/
Antígenos de Bactérias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article