Translocation (15;17) and trisomy 21 in the microgranular variant of acute promyelocytic leukemia.
Cancer Genet Cytogenet
; 132(1): 74-6, 2002 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-11801315
ABSTRACT
Cytogenetic abnormalities in acute myelogenous leukemia have been identified as one of the most important prognostic factors. Favorable chromosomal changes such as inv(16), t(8;21), and t(15;17) are associated with higher rates of complete remission and event-free survival. Translocation t(15;17) characterizes acute promyelocytic leukemia (APL) (French-American-British [FAB] class M3) in almost all patients. Secondary chromosomal abnormalities are also present in approximately one-third of patients with newly diagnosed APL. We present a 26-year-old Hispanic man diagnosed with the microgranular variant of APL (FAB class M3v) whose initial cytogenetics included t(15;17) and trisomy 21. The prognostic implications of trisomy 21 and other secondary cytogenetic aberrations in APL are reviewed. To our knowledge, this is the first reported case of trisomy 21 with t(15;17) in the microgranular variant of APL.
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Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Cromossomos Humanos Par 15
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Cromossomos Humanos Par 17
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Leucemia Promielocítica Aguda
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Síndrome de Down
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
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Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article