Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family.
Psychiatr Genet
; 11(4): 197-200, 2001 Dec.
Article
em En
| MEDLINE
| ID: mdl-11807409
ABSTRACT
The cadherin gene CELSR1 is specifically expressed in the brain and located on chromosome 22q13.33, a region that has recently been shown to be involved in the etiopathogenesis of familial catatonic schizophrenia. The gene is a strong positional candidate and was considered for mutational analysis. A total of 17 allelic variants of CELSR1 was found by sequencing all 35 exons, intron-exon junctions, and the putative promoter region by screening two patients from a large family mainly supporting this locus, and three control subjects in a first step. No variant exclusively co-segregates with the disease in the large pedigree, providing evidence that CELSR1 is not causative for the pathogenesis of catatonic schizophrenia in this family.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia Catatônica
/
Cromossomos Humanos Par 22
/
Caderinas
Limite:
Humans
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article