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Synthesis and antimicrobial activity of some 1,2,4-triazole-3-mercaptoacetic acid derivatives.
Ulusoy, N; Gürsoy, A; Otük, G.
Afiliação
  • Ulusoy N; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey. nurayulusoy@yahoo.com
Farmaco ; 56(12): 947-52, 2001 Dec.
Article em En | MEDLINE | ID: mdl-11829115
Ethyl 5-(2-furyl)-4-ethyl-1,2,4-triazole-3-mercaptoacetate (2), 5-(2-furyl)-4-ethyl-1,2,4-triazole-3-mercaptoacetic acid hydrazide (3) and a series of new N-alkylidene/arylidene-5-(2-furyl)-4-ethyl-1,2,4-triazole-3-mercaptoacetic acid hydrazides (4a-f) were synthesized and evaluated for in vitro antibacterial activity against Staphylococcus aureus ATCC 6538. Staphylococcus epidermidis ATCC 12228, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Escherichia coli ATCC 8739, Shigella flexneri, Salmonella typhi, Proteus mirabilis and antifungal activity against Candida albicans ATCC 10231 using the disk diffusion and microdilution methods. Compound 4f showed antibacterial activity against some bacteria. The in vitro antimycobacterial activity of the new compounds against Mycobacterium tuberculosis H37Rv was evaluated employing the BACTEC 460 radiometric system. The highest inhibition observed was 61% at > 6.25 microg/ml.
Assuntos
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Base de dados: MEDLINE Assunto principal: Tioglicolatos / Triazóis / Antibacterianos Idioma: En Ano de publicação: 2001 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Tioglicolatos / Triazóis / Antibacterianos Idioma: En Ano de publicação: 2001 Tipo de documento: Article