Thrombin regulation of cell function through protease-activated receptors: implications for therapeutic intervention.
Biochemistry (Mosc)
; 67(1): 56-64, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11841340
ABSTRACT
The serine protease thrombin is well recognized as being pivotal to the maintenance of hemostasis under both normal and pathological conditions. Its cellular actions are mediated through a unique family of protease-activated receptors (PARs). These receptors represent a novel family of G protein-coupled receptors that undergo proteolytic cleavage of their amino terminus and subsequent autoactivation by a tethered peptide ligand. This paper reviews the consequences of PAR activation in thrombosis, vascular injury, inflammation, tissue injury, and within the tumor microenvironment.
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Base de dados:
MEDLINE
Assunto principal:
Endopeptidases
/
Trombina
/
Receptores de Trombina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article