Effect of low protein concentration on serum sodium measurement: pseudohypernatraemia and pseudonormonatraemia!
Ann Clin Biochem
; 39(Pt 1): 66-7, 2002 Jan.
Article
em En
| MEDLINE
| ID: mdl-11853193
ABSTRACT
BACKGROUND:
The effect of high concentrations of protein or lipid on the measurement of plasma sodium by indirect ion selective electrode (ISE) causing pseudohyponatraemia and pseudonormonatraemia is well described. The effect of a low total protein concentration, however, has not been described.METHODS:
In order to examine this, over a 2-week period the total protein concentration was measured on all samples received for urea and electrolyte measurement. All samples with a low (<50 g/L) or a high (> 80 g/L) total protein concentration had sodium measured by both direct and indirect ISE.RESULTS:
There were approximately equal numbers of samples with a protein concentration less than 50 g/L (1.3%) as samples with a protein concentration greater than 80 g/L (1.3%). The frequency of erroneous sodium results owing to the use of an indirect ISE was less in hypoproteinaemic (2%) than in hyperproteinaemic (20%) samples.
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Base de dados:
MEDLINE
Assunto principal:
Sódio
/
Proteínas Sanguíneas
/
Hipernatremia
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article