Benign solitary fibrous pleural tumour. Evidence of primitive features and complex genomic imbalances, including loss of 20q.
APMIS
; 109(9): 601-6, 2001 Sep.
Article
em En
| MEDLINE
| ID: mdl-11878713
ABSTRACT
AIMS:
Cytogenetic data on solitary fibrous tumours (SFT) are very limited. We studied a benign pleural SFT for its ultrastructural and immunohistochemical details, and made cytogenetic analyses for comparison with other genetic and ultrastructural studies of SFT.RESULTS:
Immunohistochemistry showed strong positivities for CD34 and vimentin, but no reactions with anti-cytokeratins and epithelial membrane antigens. Electron microscopy revealed primitive desmosomes in our SFT. The results thus evinced fibroblast-like cells with intermediate epithelial-mesenchymal character. Comparative genomic hybridization of the tumour revealed losses of 1p33-->pter, 17pter q21, entire copies of chromosomes 19 and 22, and gains of 1p21-p22, 2q23-q32.3, 3pl2-q13.2, 4p14-q28, 6p12-q21, 9p21-->pter and 13q21-q31. Furthermore, there was loss of 20q, as was previously reported elsewhere in a case of benign and a case of malignant SFT.CONCLUSIONS:
The results furnish further evidence of the involvement of -20q in SFT. In addition, they show that SFT may have complex genomic imbalances and primitive features, despite having a benign appearance.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pleurais
/
Cromossomos Humanos Par 20
/
Deleção Cromossômica
/
Neoplasias de Tecido Fibroso
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2001
Tipo de documento:
Article