Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1.
Bioorg Med Chem Lett
; 12(7): 1063-6, 2002 Apr 08.
Article
em En
| MEDLINE
| ID: mdl-11909718
ABSTRACT
We have synthesized and evaluated a series of tetramic acid-based and hydroxyquinolinone-based inhibitors of plasminogen activator inhibitor-1 (PAI-1). These studies resulted in the identification of several compounds which showed excellent potency against PAI-1. The design, synthesis and SAR of these compounds are described.
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Base de dados:
MEDLINE
Assunto principal:
Pirrolidinonas
/
Inibidor 1 de Ativador de Plasminogênio
/
Hidroxiquinolinas
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article