Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways.
Biol Pharm Bull
; 25(3): 318-22, 2002 Mar.
Article
em En
| MEDLINE
| ID: mdl-11913525
ABSTRACT
Interleukin (IL)-5 is thought to play important roles in asthma and to be a potential therapeutic target. An intratracheal injection of murine recombinant IL-5 (3-30 microg/animal) induced a dose-dependent increase in the number of eosinophils in the bronchoalveolar lavage fluid of Brown Norway (BN) rats 24 h after administration. Bovine serum albumin (30pg/animal), used as reference material, did not cause any change. The reaction was not observed in F344 rats. The increase in the number of eosinophils did not accompany bronchial hyperreactivity in BN or F344 rats. Prednisolone (3-10 mg/kg, i.p.) and emedastine (30 mg/kg, p.o.) reduced the increased number of eosinophils induced by the IL-5 challenge. These results suggest that IL-5 is a potent inducer of eosinophils in the airway of BN rats. Prednisolone and emedastine are effective against IL-5-induced eosinophilia.
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Base de dados:
MEDLINE
Assunto principal:
Brônquios
/
Interleucina-5
/
Antialérgicos
/
Eosinófilos
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article