Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats.
Neuroreport
; 13(4): 511-4, 2002 Mar 25.
Article
em En
| MEDLINE
| ID: mdl-11930172
ABSTRACT
Protease-activated receptor-2 (PAR-2) in the sensory neurons may be involved in nociceptive processing. We attempted to detect and characterize specific expression of spinal Fos, a marker of nociception, in mast cell-depleted rats. Intraplantar (i.pl.) administration of not only the PAR-2 agonist SLIGRL-NH2, but also the control peptide LSIGRL-NH2, induced Fos expression in naive rats, whereas only the former specifically produced Fos expression in mast cell-depleted rats. This Fos expression was blocked by intrathecal DAMGO, a mu-opioid agonist, and, in part, by i.pl. calphostin C, a protein kinase C (PKC) inhibitor. Thus, specific expression of spinal Fos following peripheral PAR-2 activation is detectable in mast cell-depleted rats, suggesting activation of spinal nociceptive neurons, which is partially mediated by activation of PKC.
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Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Genes fos
/
Receptores de Trombina
/
Células do Corno Posterior
/
Mastócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article