Rhinocerebral mucormycosis in the era of lipid-based amphotericin B: case report and literature review.
Pharmacotherapy
; 22(4): 519-26, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11939688
ABSTRACT
Rhinocerebral mucormycosis (RCM) is an invasive fungal infection that necessitates, in most cases, aggressive surgical debridement and high cumulative, often nephrotoxic doses of amphotericin B. A 50-year-old woman with RCM was treated successfully with amphotericin B lipid complex as primary therapy. The patient previously had displayed progressive intracranial involvement and rising serum creatinine levels while receiving the conventional (nonlipid) form of amphotericin B. A literature review identified only a few cases where systemic antifungal therapy was administered, with minimal or no surgery. Our case further supports that amphotericin B lipid complex can be used as primary therapy in selected patients with RCM, without the need for surgical exenteration.
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Base de dados:
MEDLINE
Assunto principal:
Sinusite
/
Anfotericina B
/
Lipídeos
/
Mucormicose
/
Antifúngicos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article