Hippocampal A beta 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice.
Neurobiol Dis
; 9(3): 339-47, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11950278
ABSTRACT
We investigated the role of hippocampal amyloid pathology in spatial learning impairment of a new mouse line carrying mutated human amyloid precursor protein (APP) and presenilin-1 (PS1) transgenes. The APP + PS1 mice were tested in spatial navigation in the water maze and in position discrimination in the T-maze at ages of 3-4 and 11-12 months, before and after the appearance of first amyloid plaques. The APP + PS1 mice were impaired in water maze acquisition and retention only at the age of 11-12 months, but performed equally to controls in the T-maze task at both ages. In the impaired older age group, the levels of total Abeta1-42 in the hippocampus of APP + PS1 mice correlated negatively with the retention score. Here we show for the first time that the age-dependent impairment in memory retention in the traditional water maze of APP + PS1 mice correlates with the amount of total Abeta in hippocampus even at a stage when the amyloid deposits cover less than 1% of the hippocampal volume.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Peptídeos beta-Amiloides
/
Precursor de Proteína beta-Amiloide
/
Hipocampo
/
Proteínas de Membrana
/
Transtornos da Memória
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article