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GH-independent cardiotropic activities of hexarelin in patients with severe left ventricular dysfunction due to dilated and ischemic cardiomyopathy.
Imazio, M; Bobbio, M; Broglio, F; Benso, A; Podio, V; Valetto, M R; Bisi, G; Ghigo, E; Trevi, G P.
Afiliação
  • Imazio M; Division of Cardiology, University Internal Medicine Department, Turin, Italy.
Eur J Heart Fail ; 4(2): 185-91, 2002 Mar.
Article em En | MEDLINE | ID: mdl-11959048
ABSTRACT

AIM:

To investigate acute cardiotropic activities of hexarelin in patients with severe left ventricular dysfunction due to ischemic (iCMP) and dilated cardiomyopathy (dCMP). METHODS AND

RESULTS:

We studied the effect of intravenous hexarelin administration on growth hormone (GH) levels and left ventricular ejection fraction (LVEF) evaluated by radionuclide angiography in eight patients with dCMP (age 53.0+/-2.8, LVEF 16.7+/-2.1%) and five patients with iCMP (age 52.0+/-2.8 years, LVEF 22.6+/-2.1). Results were compared with a group of seven normal subjects (age 37.4+/-3.4 years, LVEF 64.0+/-1.5%) and seven patients with severe growth-hormone deficiency (GHD; age 42.0+/-4.4 years, LVEF 50.0+/-1.9%) previously studied with the same methodology. In dCMP and iCMP patients hexarelin induced a similar significant (P<0.05) increase in GH levels. In iCMP patients hexarelin induced a LVEF increase (peak LVEF 26.2+/-2.5%, P<0.05) as observed in normals and GHD, while in dCMP LVEF was unchanged (peak LVEF 17.7+/-1.7, P=NS). In all groups other hemodynamic parameters were unchanged.

CONCLUSIONS:

Acute hexarelin administration increases LVEF in iCMP patients (as in normals and GHD) but not in dCMP patients in spite of a similar GH releasing effect and basal LVEF. A possible explanation of the positive inotropic effect of hexarelin in iCMP could be a direct stimulation on viable myocardium or myocardial contractile reserve.
Assuntos
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Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Cardiomiopatia Dilatada / Isquemia Miocárdica / Disfunção Ventricular Esquerda / Hormônio do Crescimento Humano Tipo de estudo: Evaluation_studies Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2002 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Cardiomiopatia Dilatada / Isquemia Miocárdica / Disfunção Ventricular Esquerda / Hormônio do Crescimento Humano Tipo de estudo: Evaluation_studies Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2002 Tipo de documento: Article