Smoking before pregnancy and risk of gestational hypertension and preeclampsia.
Am J Obstet Gynecol
; 186(5): 1035-40, 2002 May.
Article
em En
| MEDLINE
| ID: mdl-12015533
ABSTRACT
OBJECTIVE:
Our purpose was to determine whether smoking before pregnancy reduces the risk of gestational hypertension or preeclampsia. STUDYDESIGN:
The trial of Calcium for Preeclampsia Prevention (CPEP) was a randomized study of 4589 nulliparous women conducted in 5 US medical centers during the years 1992 through 1995. Women were classified into 4 exposure groups by smoking history obtained at study enrollment (13-21 weeks' gestation) (1) never smoked, (2) smoked but quit before the last menstrual period (LMP), (3) smoked but quit after LMP but before enrollment, and (4) smoked and still smoking at enrollment.RESULTS:
After adjustments were made for maternal age, race, body mass index, type of health insurance, and clinical center, women smoking at enrollment had a reduced risk of hypertension (relative risk = 0.8; 95% CI, 0.6-0.9). Women who quit smoking before the LMP did not have reduced risk (relative risk = 1.1; 95% CI, 0.9-1.3). Results were similar for gestational hypertension and preeclampsia examined separately.CONCLUSION:
Women who smoke but quit before becoming pregnant do not have a reduced risk for gestational hypertension or preeclampsia.
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Base de dados:
MEDLINE
Assunto principal:
Pré-Eclâmpsia
/
Complicações Cardiovasculares na Gravidez
/
Fumar
/
Hipertensão
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article