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FGFR3 dysregulation in multiple myeloma: frequency and prognostic relevance.
Rasmussen, Thomas; Hudlebusch, Heidi Rye; Knudsen, Lene Meldgaard; Johnsen, Hans Erik.
Afiliação
  • Rasmussen T; Department of Haematology L 54P4, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark. thra@herlevhosp.kbhamt.dk
Br J Haematol ; 117(3): 626-8, 2002 Jun.
Article em En | MEDLINE | ID: mdl-12028033
ABSTRACT
The t(414) translocation affects two potential oncogenes, FGFR3 and MMSET, in multiple myeloma (MM). We investigated the frequency of FGFR3 dysregulation and its prognostic value in MM. FGFR3 mRNA levels were determined in 110 diagnostic bone marrow (BM) samples from MM patients. In addition, selected BM samples were screened for elevated MMSET mRNA levels. 14.5% (16/110) of MM BM samples showed dysregulated FGFR3 expression. Follow-up of 76 MM patients showed no significant difference between FGFR3 dysfunction and survival (P = 0.3) or correlation with known prognostic factors. Further, no linear relation was observed between FGFR3 and MMSET levels.
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Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas Tirosina Quinases / Proteínas de Transporte / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Receptores de Fatores de Crescimento de Fibroblastos / Mieloma Múltiplo Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2002 Tipo de documento: Article
Buscar no Google
Imprimir
XML
PubMed Links

Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas Tirosina Quinases / Proteínas de Transporte / Biomarcadores Tumorais / Regulação Neoplásica da Expressão Gênica / Receptores de Fatores de Crescimento de Fibroblastos / Mieloma Múltiplo Tipo de estudo: Observational_studies / Prognostic_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 2002 Tipo de documento: Article