Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling.
Oncogene
; 21(22): 3651-8, 2002 May 16.
Article
em En
| MEDLINE
| ID: mdl-12032867
ABSTRACT
Low level expression of an active Raf kinase results in a transformed phenotype; however, high intensity Raf signals block cell cycle progression. Phospholipase D (PLD) has been implicated in regulating cell cycle progression and PLD activity is elevated in Raf transformed cells. We report here that high intensity Raf signals reduce PLD activity and that elevated expression of either PLD1 or PLD2 prevents cell cycle arrest induced by high intensity Raf signals. Overexpression of either PLD1 or PLD2 also reversed increases in p21(Cip1) and protein kinase C delta (PKC delta) cleavage seen with high intensity Raf signals. These data indicate that PLD signaling provides a novel survival signal that overcomes cell cycle arrest induced by high intensity Raf signaling.
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipase D
/
Transdução de Sinais
/
Proteínas Proto-Oncogênicas c-raf
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article