Targeting peptides for microglia identified via phage display.
J Neuroimmunol
; 127(1-2): 13-21, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12044970
ABSTRACT
Screening with a 7-mer phage display peptide library, a panel of cell-targeting peptides for the murine microglial cell line, EOC 20, was recognized. A number of similar, but not identical, sets of sequences representing more than 75% of all the cell line-binding clones were identified. Comparative analysis indicated that motif S/(T) F T/(X) Y W is present in the vast majority of the binding sequences. The selectivity and specificity of the dominant peptide sequence identified for microglia was confirmed using both phage displaying the peptide and the synthetic peptide alone.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Microglia
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article