Tobacco smoke exposure and bombesin-like peptides in guinea pigs.
Peptides
; 23(5): 919-26, 2002 May.
Article
em En
| MEDLINE
| ID: mdl-12084523
ABSTRACT
Bombesin-like peptides (BLPs) are associated with tobacco smoke (TS)-induced diseases. We sought to determine if acute TS exposure releases BLPs into the pulmonary circulation. Sensitized and non-sensitized guinea pigs were chronically exposed to TS or compressed air. Thereafter, the lungs were acutely challenged with TS while perfused. Perfusates were analyzed for BLPs. TS increased BLPs in non-sensitized guinea pigs. A separate study determined daily bombesin exposure increased lung cell counts but not airway hyperresponsivensess. TS exposure releases BLPs into the pulmonary circulation but can be modified by host factors and bombesin itself does not induce airway hyperresponsiveness.
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Base de dados:
MEDLINE
Assunto principal:
Bombesina
/
Fumar
/
Pulmão
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article