The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly.
Nat Cell Biol
; 4(7): E177-84, 2002 Jul.
Article
em En
| MEDLINE
| ID: mdl-12105431
ABSTRACT
The small GTPase Ran is a key regulator of nucleocytoplasmic transport during interphase. The asymmetric distribution of the GTP-bound form of Ran across the nuclear envelope--that is, large quantities in the nucleus compared with small quantities in the cytoplasm--determines the directionality of many nuclear transport processes. Recent findings that Ran also functions in spindle formation and nuclear envelope assembly during mitosis suggest that Ran has a general role in chromatin-centred processes. Ran functions in these events as a signal for chromosome position.
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Base de dados:
MEDLINE
Assunto principal:
Proteína ran de Ligação ao GTP
/
Transporte Ativo do Núcleo Celular
/
Fuso Acromático
/
Membrana Nuclear
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article