Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages.
Cell
; 110(1): 119-31, 2002 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-12151002
ABSTRACT
Phagocytosis is a key aspect of our innate ability to fight infectious diseases. In this study, we have found that fusion of the endoplasmic reticulum (ER) with the macrophage plasmalemma, underneath phagocytic cups, is a source of membrane for phagosome formation in macrophages. Successive waves of ER become associated with maturing phagosomes during phagolysosome biogenesis. Thus, the ER appears to possess unexpectedly pluripotent fusion properties. ER-mediated phagocytosis is regulated in part by phosphatidylinositol 3-kinase and used for the internalization of inert particles and intracellular pathogens, regardless of their final trafficking in the host. In neutrophils, where pathogens are rapidly killed, the ER is not used as a major source of membrane for phagocytosis. We propose that intracellular pathogens have evolved to adapt and exploit ER-mediated phagocytosis to avoid destruction in host cells.
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Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Fagossomos
/
Retículo Endoplasmático
/
Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article