Influence of implantation interval on the long-term biocompatibility of surgical mesh.
Br J Surg
; 89(8): 1043-8, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12153633
ABSTRACT
BACKGROUND:
The aim was to study the long-term tissue response to polypropylene mesh.METHODS:
This was a retrieval study that investigated 76 polypropylene meshes with a median implantation interval of 18 (range 2-180) months. Mesh was explanted following hernia recurrence, infection or pain. The median implantation interval was 20 (range 4-180) months in the recurrence group, 30 (range 5-48) months in the pain group and 10 (range 2-56) months in the infection group (P < 0.05, infection versus pain or recurrence). The inflammatory response was determined by immunohistochemistry of macrophages (CD68), polymorphonuclear granulocytes (CD15) and T and B lymphocytes (CD3 and CD20). The cell turnover within the interface mesh fibre-recipient tissue was measured by TUNEL for apoptosis or DNA strand breaks, Ki67 for cell proliferation and heat-shock protein (HSP) 70 for cell stress.RESULTS:
With the exception of HSP-70, levels of all variables decreased over time. Sex, age, type of previous operation or location of the mesh did not have a significant influence.CONCLUSION:
Long-term incorporated polypropylene mesh in humans has a more favourable tissue response with increasing implantation interval.
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Base de dados:
MEDLINE
Assunto principal:
Polipropilenos
/
Telas Cirúrgicas
/
Herniorrafia
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article