Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.
Bioorg Med Chem Lett
; 12(17): 2415-8, 2002 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-12161146
ABSTRACT
A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.
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Base de dados:
MEDLINE
Assunto principal:
Propionatos
/
Integrina alfa4beta1
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article