Exposure and nasal inflammation in workers heating polyurethane.
Int Arch Occup Environ Health
; 75(7): 468-74, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12172893
ABSTRACT
OBJECTIVE:
To test the hypothesis that exposure to thermal-degradation products of polyurethane (PUR), particularly isocyanates, induced nasal inflammation.METHODS:
Thirty-eight workers -14 with a history of work-related nasal symptoms (WRS/Nose), and 15 referents without such history - exposed to sprayed and heated PUR glue, were studied with regard to biomarkers of isocyanate exposure [4,4'-diphenylmethane diisocyanate (4,4'-methylenediphenyl diisocyanate; MDI) and 2,4- and 2,6-toluene diisocyanate (TDI), determined as 4,4'-diphenylmethane (U-MDX) and 2,4- and 2,6-toluene (U-2,4 and U-2,6-TDX) diamine in hydrolysed urine and nasal lavage fluid (NAL)], inflammation [albumin; eosinophilic cationic protein (ECP); myeloperoxidase (MPO) and cells in NAL], serum IgG specific for MDI (S-IgG-MDI) and TDI (S-IgG-TDI), and nose symptoms. Nine unexposed office workers were also examined.RESULTS:
The exposure to sprayed and heated PUR glue, especially when heated by gun, was associated with the presence of biomarkers of isocyanate exposure in urine; after work the levels [median (range)] in all workers were U-MDX 0.32 (CONCLUSIONS:
The present data indicate that thermal degradation products of PUR induced a 'chronic' rhinitis. At exposure, there was an accentuation of symptoms; the signs of acute inflammation were less obvious.
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Base de dados:
MEDLINE
Assunto principal:
Poliuretanos
/
Rinite
/
Exposição Ocupacional
/
Temperatura Alta
/
Cavidade Nasal
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article