Effects of early treatment with growth hormone on infarct size, survival, and cardiac gene expression after acute myocardial infarction.
Growth Horm IGF Res
; 12(4): 208-15, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12175653
ABSTRACT
OBJECTIVE:
This study examined the effects of growth hormone (GH) on infarct size, survival, and cardiac gene expression in rats with acute myocardial infarction.DESIGN:
Animals randomly received sc injection of either saline vehicle (n = 98) or GH (2mg/kg/day, n = 105) for 14 days commencing the day of left coronary artery ligation. Infarct size was determined by morphometric analysis at the time of death or at 52 weeks post-surgery. Gene expression was analyzed by real-time RT-PCR after 2-week treatment.RESULTS:
GH decreased infarct size by 18% (P < 0.01) and increased survival by 36% at 52 weeks. GH also significantly reduced cardiac expression of atrial natriuretic factor, beta-myosin heavy chain, alpha-smooth muscle actin, collagen I, collagen III, fibronectin, and pro-inflammatory cytokines.CONCLUSIONS:
Treatment with GH for 2 weeks beginning on the day of myocardial infarction produced beneficial effects that were associated with reductions in cardiac gene expression symptomatic of pathological remodeling.
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Base de dados:
MEDLINE
Assunto principal:
Hormônio do Crescimento
/
Regulação da Expressão Gênica
/
Coração
/
Infarto do Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article