CD3+CD4-CD8+NK- large granular lymphocytosis with neutropenia and evidence for clonality and T-cell receptor gene rearrangement: two pediatric cases.
J Pediatr Hematol Oncol
; 24(6): 495-8, 2002.
Article
em En
| MEDLINE
| ID: mdl-12218601
ABSTRACT
The authors describe two pediatric cases of large granular lymphocytosis presenting early in the second decade of life with neutropenia and sepsis. They are among the youngest described in the literature. This report focuses on the advantages of detailed immunophenotypic and molecular analysis and highlights some of the controversies and uncertainties in the management of these patients, particularly the choice of immunosuppressive therapy. Immunosuppressive therapy in the two children described in this report resulted in improvement of neutropenia and clinical status, but this was not accompanied by the disappearance of the clonal population.
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Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Linfócitos T CD4-Positivos
/
Receptores de Antígenos de Linfócitos T alfa-beta
/
Rearranjo Gênico da Cadeia beta dos Receptores de Antígenos dos Linfócitos T
/
Complexo CD3
/
Linfócitos T CD8-Positivos
/
Linfocitose
/
Neutropenia
Limite:
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article