Saccopetrins A and B, two novel gamma-lactones from Saccopetalum prolificum.
Planta Med
; 68(8): 719-22, 2002 Aug.
Article
em En
| MEDLINE
| ID: mdl-12221595
ABSTRACT
Two new gamma-lactones, saccopetrin A (1) and saccopetrin B (2), together with 10 known compounds have been isolated from the roots of Saccopetalum prolificum. Their structures were established by spectroscopic and chemical methods. The absolute configuration of 1 was determined by chemical transformation and the Mosher method. Cytotoxic activities were evaluated against several different cell lines. Compound 2 exhibited stronger cytotoxic activities than 1 against KB and HCT-8 cell lines at a concentration of 10(-5) mol/L.
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Base de dados:
MEDLINE
Assunto principal:
Annonaceae
/
Quassinas
/
Lactonas
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article