Bioactive phenolic derivatives from Acaena splendens methanol extract.
Phytother Res
; 16(6): 562-6, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12237815
Acaena splendens H. et A. has been used in Chilean folk medicine for the treatment of fever and inflammation. A description of the in vivo reduction of bacterial pyrogen-induced fever in rabbits and carrageenan-induced paw oedema in guinea pigs is presented. The methanol extract named ME-1, obtained after succesive extractions with petroleum ether and dichloromethane, showed a strong antipyretic action (45.7% of effect), though the antiinflammatory activity was only observed after submitting this extract to column fractionation, giving a crude mixture of flavonoids named C4 with both activities (55.7% and 98.9% of antiinflammatory and antipyretic effect respectively at a dose of 600 mg/kg). The bioassay-guided fractionation by column chromatography afforded the active fraction, which contained (-,-)-epicatechin, tiliroside, 7-O-acetyl-3-O-beta-D-glucosyl-kaempferol and 7-beta-D-glucosyloxy-5-hydroxy-chromone.
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Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Extratos Vegetais
/
Rosaceae
/
Quempferóis
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article