CD44 signaling through focal adhesion kinase and its anti-apoptotic effect.
FEBS Lett
; 528(1-3): 101-8, 2002 Sep 25.
Article
em En
| MEDLINE
| ID: mdl-12297287
ABSTRACT
Adhesion molecules can initiate intracellular signaling. Engagement of CD44 either by its natural ligand hyaluronan or a specific antibody on a cell line induced tyrosine phosphorylation and activation of focal adhesion kinase (FAK), which then associated with phosphatidylinositol 3-kinase (PI3K) and activated mitogen-activated protein kinase at its downstream. However, the introduction of dominant negative Rho into the cells inhibited the CD44-stimulated FAK phosphorylation. Cells expressing CD44 were significantly resistant to etoposide-induced apoptosis. This anti-apoptotic effect was cancelled by the inhibition of either Rho, FAK or PI3K. These results may indicate a signaling pathway from CD44 to mediate the resistance against drug-induced apoptosis in cancer cells.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Tirosina Quinases
/
Apoptose
/
Receptores de Hialuronatos
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article