A prospective study of the clarithromycin-digoxin interaction in elderly patients.
J Antimicrob Chemother
; 50(4): 601-6, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12356809
ABSTRACT
The study was a prospective observational trial carried out to assess the clarithromycin-digoxin interaction in elderly patients chronically taking digoxin. Digoxin concentrations were determined before and after concomitant treatment with clarithromycin. A Bayesian approach was used to calculate digoxin pharmacokinetics. In the seven patients who were studied there was a significant increase in digoxin concentration after 4-7 days of clarithromycin treatment; digoxin clearance and elimination rate constant were 56-60% lower and elimination half-life was 82% longer. The pharmacokinetic clarithromycin-digoxin interaction in the elderly may be much more frequent than has been assumed up to now.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Claritromicina
/
Digoxina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article