Stereochemical studies of adrenergic drugs. Optically active derivatives of imidazolines.
J Med Chem
; 19(12): 1382-4, 1976 Dec.
Article
em En
| MEDLINE
| ID: mdl-12368
ABSTRACT
The synthesis of (R)-(+)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride (2) and (S)-(-)-4-methyl-2-(1-naphthylmethyl)imidazoline hydrochloride (3) is presented. The synthesis involves the preparation of (R)-(+)- and (S)-(-)-1,2-diaminopropane dihydrochloride and then allowing the appropriate diaminopropane to react with ethyl 1-naphthyliminoacetate hydrochloride in the presence of triethylamine. The parent compound, naphazoline, is a potent alpha-adrenoreceptor agonist (-log ED50 = 7.22), whereas the methylated derivatives, 2 and 3, were moderately potent antagonists (pA2 = 5.6 and 5.8, respectively) of the alpha-adrenoreceptor. Compounds 2 and 3 also produced blockade of the response to histamine on the rabbit aorta, but at concentrations approximately 20 times higher than necessary to produce equal blockade of the alpha-adrenoreceptor.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Adrenérgicos
/
Receptores Adrenérgicos alfa
/
Imidazóis
/
Nafazolina
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article