Effect of two long acting injectable progestogens on lactation in the human.

ABSTRACT

The effects of Depoprovera and Deladroxone were studied in humans, on certain milk components as well as on the growth of the nursed infants. Both drugs caused reduction in milk yield. Both drugs caused an increase in the concentration of milk total proteins, however. Depoprovera caused an increase while Deladroxone caused a decrease in the total amount of milk proteins per feed. Depoprovera showed no effect while Deladroxone caused an increase in the concentration of milk lipids; however, both drugs caused reduction in the total amount of milk lipids per feed. Both drugs showed no effect on the concentration of milk lactose, but caused reduction in the total amount of milk lactose per feed. The percentage increase in weight of nursed infants was decreased by Depoprovera, but not affected by Deladroxone.

ABSTRACT

PIP The effects of Depo Provera and Deladroxone, both long-acting inject able contraceptive agents, on lactation and infant growth was studied in 76 lactating women. Milk yield was decreased by both drugs, though the concentration of total milk proteins was increased. Depo Provera increased the total amount of milk proteins per feed, while a decrease was observed with Deladroxone. Deladroxone increased the concentration of milk lipids, but Depo Provera had no effect. Nonetheless, both agents reduced the total amount of milk lipids per feed. Concentrations of milk lactose were unaffected, but the total amount of milk lactose per feed was reduced by both drugs. Depo Provera decreased the rate of infant growth, while Deladroxine had no effect.