Delayed and prolonged cholestatic hepatitis with ductopenia after long-term ciprofloxacin therapy for Crohn's disease.
J Hepatol
; 37(5): 696-9, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12399240
ABSTRACT
Ciprofloxacin, a fluorinated quinolone, is a powerful antibiotic widely used for its broad spectrum of activity in ambulatory and long-term care setting. Until now, ciprofloxacin administration has been associated with a few cases of acute, sometimes cholestatic jaundice or fulminant hepatic failure believed mainly related to idiosyncratic hypersensitivity. We report a case of delayed and prolonged cholestatic hepatitis with ductopenia occurring after 6 months of treatment in a patient with Crohn's disease. This observation suggests the potential for the drug to induce long-term likely dose-related severe hepatotoxicity.
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Base de dados:
MEDLINE
Assunto principal:
Ductos Biliares
/
Doença de Crohn
/
Ciprofloxacina
/
Colestase
/
Doença Hepática Induzida por Substâncias e Drogas
/
Anti-Infecciosos
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article