23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.
Life Sci
; 72(1): 1-9, 2002 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-12409140
ABSTRACT
23-Hydroxybetulinic acid, a derivative of betulinic acid, was investigated for its apoptotic effect and the associated telomerase activity in human leukemia HL-60 cells. Apoptosis and bcl-2 were determined by flow cytometry analysis. A PCR-based telomeric repeat amplification protocol assay was used to detect telomerase activity. Results showed that 23-hydroxybetulinic acid induced growth arrest and apoptotic cell death in HL-60 cells. The apoptotic events were associated with concurrent down-regulation of bcl-2 and the telomerase activity. Our data suggest that 23-hydroxybetulinic acid may be a potential cytotoxic agent for treatment of cancer.
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
/
Apoptose
/
Telomerase
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Antineoplásicos Fitogênicos
Tipo de estudo:
Guideline
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article