Treatment of chronic wounds by local delivery of granulocyte-macrophage colony-stimulating factor in patients with neutrophil dysfunction.
Pediatr Surg Int
; 18(5-6): 517-20, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12415398
ABSTRACT
Chronic wounds are associated with considerable morbidity and prolonged hospitalizations. The availability of recombinant growth factors and cytokines provides a new modality for treatment of recalcitrant wounds. Granulocyte-macrophage colony-stimulating factor (GM-CSF), a growth protein for hematopietic cells, also enhances neutrophil and monocyte function and promotes keratinocyte proliferation. In three patients with inherited disorders associated with leukocyte dysfunction and non-healing wounds, topical application of GM-CSF resulted in complete wound closure within 1 to 4 weeks. A subcutaneous (s.c.) infusion pump for the local s.c. delivery of GM-CSF was also found to enhance healing. Local application of GM-CSF may thus promote wound closure in patients with impaired wound healing.
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Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Doença de Depósito de Glicogênio Tipo I
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
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Sistemas de Liberação de Medicamentos
/
Doença Granulomatosa Crônica
Limite:
Adolescent
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article