NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.
Acta Biochim Pol
; 49(3): 597-614, 2002.
Article
em En
| MEDLINE
| ID: mdl-12422230
ABSTRACT
RNA nucleoside triphosphatases (NTPase)/helicases represent a large family of proteins that are ubiquitously distributed over a wide range of organisms. The enzymes play essential role in cell development and differentiation, and some of them are involved in transcription and replication of viral single-stranded RNA genomes. The enzymatic activities of a NTPase/helicase were also detected in the carboxyl-terminal non-structural protein 3 (NS3) of members of the Flaviviridae family. The crucial role of the enzyme for the virus life cycle was demonstrated in knock out experiments and by using NTPase/helicase specific inhibitors. This makes the enzyme an attractive target for development of Flaviviridae-specific antiviral therapies. This review will summarize our knowledge about the function and structure of the enzyme, update the spectrum of inhibitors of the enzymatic activities of the NTPase/helicase and describe the different mechanisms by which the compounds act. Some of the compounds reviewed herein could show potential utility as antiviral agents against Flaviviridae viruses.
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Base de dados:
MEDLINE
Assunto principal:
Flaviviridae
/
Hidrolases Anidrido Ácido
/
DNA Helicases
/
Inibidores Enzimáticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article