Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells.
Cancer Biol Ther
; 1(3): 287-90, 2002.
Article
em En
| MEDLINE
| ID: mdl-12432279
ABSTRACT
Selenium is an essential micronutrient that is currently being tested for prostate cancer chemoprevention. In spite of its significant promise as a chemopreventive agent, the molecular mechanisms of selenium-mediated effects remain to be elucidated. Recent evidence suggests that selenium may mediate its chemopreventive effects by inducing apoptosis in human prostate cancer cells. Here we report that selenium-mediated apoptosis appears to involve membrane death receptor, DR5-dependent pathway in human prostate cancer cells. Selenium specifically upregulated DR5 expression but not that of DR4. Selenium upregulation of DR5 was coupled with caspase 8 activation and Bid cleavage thereby suggesting the existence of a potential cross-talk between the DR5 and the mitochondrial pathways. Thus, our results suggest that DR5 is specifically regulated by selenium and its activation may play an important role in selenium-mediated chemoprevention.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Selênio
/
Regulação Neoplásica da Expressão Gênica
/
Apoptose
/
Receptores do Fator de Necrose Tumoral
/
Proteínas de Arabidopsis
/
Antioxidantes
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article