Acute myelogenous leukemia and glycogen storage disease 1b.
J Pediatr Hematol Oncol
; 24(9): 756-8, 2002 Dec.
Article
em En
| MEDLINE
| ID: mdl-12468919
ABSTRACT
Glycogen storage disease 1b (GSD 1b) is caused by a deficiency of glucose-6-phosphate translocase and the intracellular accumulation of glycogen. The disease presents with failure to thrive, hepatomegaly, hypoglycemia, lactic acidosis, as well as neutropenia causing increased susceptibility to pyogenic infections. We present a case of a young woman with GSD 1b who developed acute myelogenous leukemia while on long-term granulocyte colony-stimulating factor therapy. The presence of two rare diseases in a single patient raises suspicion that GSD 1b and acute myelogenous leukemia are linked. Surveillance for acute myelogenous leukemia should become part of the long-term follow-up for GSD 1b.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
/
Doença de Depósito de Glicogênio Tipo I
/
Fator Estimulador de Colônias de Granulócitos
Limite:
Female
/
Humans
/
Infant
Idioma:
En
Ano de publicação:
2002
Tipo de documento:
Article